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KMID : 0356619970120010011
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Journal of Korean Society of Endocrinology
1997 Volume.12 No. 1 p.11 ~ p.15
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Serum Lipoprotein(a) and Lipid Concentrations in Patients with Subclinical Hypothyroidism
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김경아/Kim, Kyoung Ah
정재훈/김연선/안규정/고은미/민용기/이명식/Chung, Jae Hoon/Kim, Yeun Sun/Ahn, Kyu Jeung/Koh, Eun Mi/Min, Yong Ki/Lee, Myung Shik
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Abstract
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Background; Overt hypothyroidism is well-known cause of secondaty hyperlipidemia and atheroshlerosis. However, there have been dissenting reports of abnormalities in serum lipid concentrations in patients with subclinical hypothyroidism (SH). Recently, it has been reported that serum Lp(a) concentration, an independent risk factor of atheroshclerosis, was increased in patioents with SH. Therefore, we analyzed serum Lp(a) and other lipid concentrations to investigate whether they are increased in patients with SH and the correlation between serum Lp(a) and TSH concentrations.
Methods: We undertook this study in 53 patients with SH (TSH ＞ 6 μIU/ml) and 197 age- and sex-matched healthy control subjects. They had no abnormalities in liver function, BUN, creatinine, fasting bolld glucose, urinalysis, and past medical histories. Serum T₃,T₄, and TSH concentrations were measured by RIA using commercial kits. Serum concentrations of Lp(a), total cholesterol, triglyceride (TG), and HDL cholesterol (HDL-C) were measured by rate nephelometry and enzyme assay, respectively.
Results: There were no significant differences of serum Lp(a), total cholesterol, LDL cholesterol, TG, and HDL-C concentrations in 53 patients with SH and 197 control subjects(25.6±3.8mg/dL vs. 25.4±1.5mg/dL ; 204.0±4.2mg/dL vs. 204.0±2.4mg/dL vs. 127.0±3.9mg/dL vs. 125.0±2.3mg/dl ; 133.0±8.5mg/dL vs. 130.0±6.0mg/dL ; 50.0±1.5mg/dL vs. 53.0±0.9mg/dL). There was no cerrelation between Lp(a) and TSH concentrations in SH(r=0.12, p＞0.05)
Conclusion: Serum Lp(a) concentration as well as total cholesterol, LDL cholesterol, and TG was not increased in patients with SH. There was no correlation between serum Lp(a) and TSH levels in subclinical hypothyroidism. (J Kor Soc Endocrinol 12:11~17, 1997)
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